BACKGROUND Effects of prenatal iron supplementation on maternal postpartum iron status and early infant iron homeostasis remain largely unknown. OBJECTIVE We examined iron absorption and growth in exclusively breastfed infants in relation to fetal iron exposure and iron status during early infancy. DESIGN Longitudinal, paired iron-absorption (⁵⁸Fe) studies were conducted in 59 exclusively b...

P-5m, an octapeptide derived from domain 5 of HKa, was initially found to inhibit the invasion and migration of melanoma cells. The high metastatic potential of melanoma cells was prevented by the HGK motif in the P-5m peptide in vitro and in an experimental lung metastasis model, suggesting that P-5m may play an important role in the regulation of tumor metastasis. The aim of this study was to...

Photolysis of [M(CO)6] (M /Cr, W) in CH2Cl2 at /78 8C generates [(CO)5M(CH2Cl2)]. Subsequent sequential reaction of [(CO)5M(CH2Cl2)] with terminal alkynes, HC /CR (R /COOMe, Ph, p -Tol), and diazoalkanes, R (R)CN2 (R 1 /Me, Et, Ph; R2 /Me, Et) affords 3H -pyrazole complexes, [(CO)5M / N N C(R) C(H) C /(R)(R)]. These complexes are derived from addition of diazoalkanes to alkyne complex intermedi...

Modified DNA bases in mammalian genomes, such as 5-methylcytosine ((5m)C) and its oxidized forms, are implicated in important epigenetic regulation processes. In human or mouse, successive enzymatic conversion of (5m)C to its oxidized forms is carried out by the ten-eleven translocation (TET) proteins. Previously we reported the structure of a TET-like (5m)C oxygenase (NgTET1) from Naegleria gr...